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BOPPP Trial
Supported by King's College NHS Foundation Trust

BOPPP is OPEN to recruitment!

Welcome to the BOPPP Trial website – “Beta blockers Or Placebo for Primary Prophylaxis of oesophageal varices in cirrhosis (BOPPP). A triple blinded, multi-centre, clinical- and cost-effectiveness randomised controlled trial.”

Funded by the National Institute of Health Research (NIHR) Health Technology Assessment (HTA) programme, the BOPPP trial aims to test if early use of a common beta-blocker is a cost-effective treatment to prevent bleeding in patients with liver cirrhosis and small blood vessels in the gullet. 

Sponsored by King’s College Hospital NHS Foundation Trust (KCH) at Denmark Hill, the BOPPP Trial will take place over 6 years and will recruit 1200 patients from 29 Hospitals, with at least 3 years follow up. A more detailed study summary is downloadable here [PDF of trial summary].

BOPPP Patient Perspective Video – Perspective from a patient that was recruited into the trial mid-pandemic, during the 2020 UK wide lockdown.