News

As of 16th October 2023, we have recruited 621 participants to BOPPP!

• An all-inclusive F2F collaborators’ meeting has been arranged for Thursday 6th October 2022 and subsequently, a year later, on Friday 6th October 2023

Links to latest posts:

• 600 participants randomised
• BOPPP Collaborators’ Meeting – 6th Oct 2023
• BOPPP Collaborators’ Meeting – 6th Oct 2022
• 400 patients randomised!
• We have almost reached 400 patients!

August – October 2022

• MSTeams refresher training drop-in sessions for existing sites scheduled for:
  • Wednesday 3^rd August @ 3pm
  • Thursday 18^th August @ 4pm
  • Friday 2^nd September @ 2:30pm
  • Tuesday 27^th September @ 10am
  • Wednesday 12^th October @ 9:30am
• If you’d like to attend, please send an email to kch-tr.boppptrial@nhs.net and we will get back to you ASAP.

May – July 2022

• Zoom refresher training drop in sessions for existing sites scheduled for:
  • Tuesday 24th May: 4 – 4:45pm
  • Thursday 27th May: 3 – 3:45pm
  • Tuesday 28th June: 4 – 4:45pm
  • Tuesday 12th July: 10:30 – 11:15am
• Ix Meeting #2: Tuesday 14th June: 4 – 5pm
• RN Meeting #2: Tuesday 5th July: 2 – 3pm

December 2021

• 200th participant recruited to BOPPP

November 2021

• Ix Meeting #1: Monday 8th November: 4 – 5pm

July 2021

• Planned restart on Monday 5th July 2021

June 2021

• Zoom refresher training drop in sessions for existing sites scheduled for:
  • Thursday 17^th June: 2 – 2:45pm
  • Wednesday 23^rd June: 2 – 2:45pm
  • Tuesday 29^th June: 9 – 9:45am
  • Thursday 1^st July: 2 – 2:45pm

December 2020

• Trial paused due to COVID-19 as per recommendations
• Existing sites encouraged to pre-screen for potential eligible patients

September 2020

• Database change for protocol v1.5
• Source document worksheets updated

August 2020

• Newcastle re-opens to recruitment

July 2020

• PRUH and St George’s re-open to recruitment

June 2020

• KCH is first site to re-open recruitment following COVID-19 pause.
• Guidance document v3.0 sent out to sites as to the procedure for restart

March 2020

• Trial paused on 19th March 2020 due to COVID-19 pandemic
• Guidance document v2.0 sent out for sites on how to manage their 6-monthly visits remotely

August 2019

• BOPPP joins Twitter – catch us on @boppptrial 
• Derby recruits their first patient!
• Derby, Brighton, Frimley and the Royal Free become the 2^nd, 3^rd, 4^th and 5^th sites to be opened to recruit patients!
• Nottingham and Devon & Exeter complete their Site Initiation Visit
• Nottingham, Devon & Exeter confirm capability and capacity
• BOPPP receives 
  • REC Favourable Opinion for clinical trial Protocol v1.4
  • HRA approval for clinical trial Protocol v1.4
  • Regulatory approval from the MHRA for clinical trial Protocol v1.4

July 2019

• Royal Free confirm capability and capacity
• St George’s, Frimley, Imperial and Royal Free complete their Site Initiation Visit 

June 2019

• The first UK patient is recruited at King’s College Hospital – Denmark Hill
• PRUH, Brighton, Plymouth and Derby complete their Site Initiation Visit 
• King’s College Hospital – Denmark Hill is the first site to be opened to recruit patients! 
• Frimley, Plymouth and Derby confirm capability and capacity

May 2019 

• The first confirmation of site capability and capacity to deliver BOPPP is provided by King’s College Hospital NHS Foundation Trust that covers Denmark Hill and PRUH
• St George’s confirm capability and capacity
• The Trial Management Group host a Pan-London and Co-applicant Investigator meeting involving King’s College Hospital – Denmark Hill, King’s College Hospital – Princess Royal University Hospital (PRUH), St Georges, Imperial, Frimley, Royal Free and Barts

April 2019

• BOPPP receives approval to start the trial from the Health Research Authority (HRA) for clinical trial Protocol v1.3

March 2019

• BOPPP receives Research Ethics Committee (REC) Favourable Opinion for clinical trial Protocol v1.3
• BOPPP receives regulatory approval from the Medicines & Healthcare products Regulatory Authority (MHRA) for clinical trial Protocol v1.3

January 2019

• The BOPPP trial research grant starts with permission form the Department of Health and the NIHR

October 2018

• King’s Health Partners make a press release promoting the BOPPP Trial

September 2018

• British Liver Trust make a press release promoting the BOPPP Trial

British Liver Trust supporting new research into treatment of varices

July 2018

• NIHR-HTA award the grant to Dr Vishal Patel and collaborators
• For further information see the Funding award page on National Institute for Health Research website.